Molecular analyses of DNA helicases involved in the replicational stress response
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms involved in initiation of the DNA damage response
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pat...
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DNA helicases are proteins that use the energy of NTP hydrolysis to processively denature duplex DNA.' As such, helicases can be considered similar to other mechanochemical motors that can catalyze directional movement along a polymeric lattice (e.g., microtubule-based motors as kinesin). Acting during DNA replication, helicases convert the duplex DNA to single strands and thereby activate the ...
متن کاملDna Helicases
In all organisms, genetic information is locked within a double helix formed by the two antiparallel deoxyribonucleic acid (DNA) strands. Although double-stranded DNA (dsDNA) is suitable for secure information storage, hydrogen bonds formed between complementary bases impair readout of this information by the cellular machineries that frequently require single-stranded DNA (ssDNA) as the templa...
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Jezewska, 1995). The conformation of the hexamer is DNA helicases play essential roles in key biological proaltered by ATP and DNA binding, and two distinct allocesses such as the replication, repair, recombination, steric states (exhibiting 3-fold or 6-fold symmetry) have and transcription of DNA. Their presence and imporbeen observed (Yu et al.,1996). The C3 structure appears tance in DNA met...
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چکیده یکی از مهمترین دغدغه های بزرگ جوامع بشری، از دیر باز تا کنون که ذهن پژوهشگران و متخصصان بهداشت روانی و اجتماعی و دولتها رابه خود مشغول داشته، مسأله ی بزهکاری می باشد. شناخت کامل پدیده ی بزهکاری و بزهکار، علل وعوامل سقوط یک انسان، چگونگی درمان وی و درنهایت پیشگیری ازبزهکاری ودریک کلام سالم سازی یک جامعه، رسالت عظیم، انسانی ومقدسی می باشد که با بررسی شخصیت مجرم یعنی[ انسانی که تحت شرای...
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ژورنال
عنوان ژورنال: Methods
سال: 2010
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2010.02.021